杭州浙大迪迅生物基因工程有限公司

RATIONALE: Peanut is an important food allergen because of its clinical severity and increasing prevalence, especially in some western countries. However few data came from China.METHODS: A careful history; skin prick test for peanut; specific IgE for peanut (ImmunoCAP); peanut challenge test, SDS-PAGE electrophoresis for peanut extract, immunoblot.

House dust mites (HDMs) represent one of the most important inducers of respiratory allergies worldwide.

Prior studies indicate that hazelnut component testing (HCT) may serve as a better indicator for clinical reactivity than skin prick (SPT) and hazelnut-specific IgE testing (hIgE) in patients with birch pollen allergy. The efficacy of HCT in determining clinical reactivity represents a potential gap in clinical management.

Tree nuts allergy is one of the most common food allergies. In our study we evaluate the sensitization profile in our population.

Food allergy to hazelnut occurs both with and without concomitant pollen allergy.

Soy allergy is one of the most common food allergies. The presence of IgE specific to soy component storage proteins Gly m4, m5, and m6 has been indicated as a means to improve the specific identification of systemic and local soy allergic reactions.

Incidence of food allergy is increasing, including diseases with apparently unique pathophysiologic pathways such as eosinophilic esophagitis (EoE), milk anaphylaxis and galactose-alpha-1,3-galactose (alpha-gal) allergy. The role of IgE in these diseases has been well studied, though the contribution of other antibody subtypes, including IgG4, is less clear.

Previous studies have demonstrated insufficient sensitivity of commercially available celeriac extract reagents in the diagnosis of celeriac allergy.

Sensitization to wheat flour plays an important role in the development and diagnosis of baker's asthma.

Detection of IgE to recombinant Hymenoptera venom allergens has been suggested to improve the diagnostic precision in Hymenoptera venom allergy. However, the frequency of sensitization to the only available recombinant honeybee venom (HBV) allergen, rApi m 1, in patients with HBV allergy is limited, suggesting that additional HBV allergens might be of relevance.

Eosinophilic esophagitis (EoE) is associated with specific IgG4 antibodies (sIgG4) to common foods, especially cow’s milk (CM). Little is known regarding the epidemiology of sIgG4 to CM or other foods in the general population. Thus, the diagnostic utility of IgG4 assays is unclear.

Background: Pollen-food syndrome (PFS) is heterogeneous with regard to triggers,severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of PFS based on IgE sensitization to panallergens.

Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response. We investigated the IgE reactivity of recombinant Der p 13 (rDer p 13), its lipid-binding activities, and its capacity to stimulate airway epithelium cells.

Der p 23 was recently identified in a European population as a major allergen and potentially a chitin binding protein.

To establish by oral food challenge the proportion of children with clinical peanut allergy among those considered peanut-sensitized by using skin prick tests and/or IgE measurement, and to investigate whether component-resolved diagnostics using microarray could differentiate peanut allergy from tolerance.

A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans.

Increasing dairy consumption in China has been accompanied by rising incidence of milk allergy. Here we analyzed profiles of specific immunoglobulin E (sIgE) against cow's milk proteins, and assessed their value for milk allergy diagnosis among infants and young children from northern China.

Egg allergy is the most common food allergy in children with atopic dermatitis (AD). This study aimed to determine the prevalence of egg allergy, component patterns and predictive values of screening tests in egg allergy in South African children with AD.

The purpose of this study was to evaluate the utility of cow’s milk components specific IgE levels in predicting clinical tolerance in patients with milk allergy.

We report a case of an eleven years old girl who was referred to our Allergy Outpatient Clinic for the revaluation of a hazelnut allergy. During her infancy she was successfully desensitised to milk and egg. Afterward she had been followed by another Allergy Unit where, according to skin prick test and specific IgE dosage, it had been suggested to strictly avoid peanut and all treenuts, although clinical history was not suggestive of treenuts allergy. She was also provided with an auto-injectable adrenaline, due to the high risk of severe reactions to treenuts. No oral provocation test was performed to validate diagnosis and adrenaline prescription.