杭州浙大迪迅生物基因工程有限公司

　　原标题：榛子过敏原组份检测在确定榛子敏感性中的作用
　　①以前的研究表明，与皮肤点刺试验(SPT)和榛子特异性IgE检测 (hIgE)相比，榛子组分检测(HCT)可能是桦树花粉过敏患者临床反应性更好的指标。榛子过敏原组份检测在确定临床反应性中的有效性表明在目前的临床管理中存在潜在的不足。②回顾性分析了6例进行了包含Cor a1、8、9、14的榛子过敏原组份检测的病例。由于之前的过敏试验和榛子特异性IgE检测呈阳性(1例患者SPT阳性)，榛子过敏原组份检测时没有患者食用含有榛子的产品(PCH)。四名患者在过敏测试前报告了对榛子产品的耐受性，一名患者没有接触过榛子产品，一名患者在摄入榛子产品后喉咙发痒。对统计数据、桦树花粉特异性IgE (bIgE)、榛子特异性IgE水平、SPT结果、榛子Cor a 1、8、9、14特异性IgE水平和榛子产品激发试验结果以图表方式进行回顾性分析。③总IgE平均值为411.11（SD: 529.07; N: 6），榛子特异性IgE平均值为15.95（SD=17.36; N=6），桦树花粉特异性IgE平均值为9.57（SD=45.06; N=6），Cor a 1=29.85 (SD=40.16; N=6), Cor a 8=0.1 (SD=1.52; N=6), Cor a 9=0.34 (SD=0.53; N=6), and Cor a 14=0.27 (SD=0.27; N=6).6例中的5例在他们的饮食中引入榛子产品，他们的Cor a 1=35.80 (SD=41.84; N=5)，Cor a 9=0.12 (SD=0.06; N=5)，而饮食中没有引入榛子产品的那例病人Cor a 1=0.1 和 Cor a 9=1.43④这是对榛子组份检测作用的初步研究，本研究显示，榛子组份检测能确定榛子特异性IgE阳性的桦树花粉过敏病人的临床反应性。
延伸阅读
JACI:
The Efficacy of Hazelnut IgE Component Testing in Determining Hazelnut Sensitivity
DOI: https://doi.org/10.1016/j.jaci.2017.12.773
Abstract:
Rationale
Prior studies indicate that hazelnut component testing (HCT) may serve as a better indicator for clinical reactivity than skin prick (SPT) and hazelnut-specific IgE testing (hIgE) in patients with birch pollen allergy. The efficacy of HCT in determining clinical reactivity represents a potential gap in clinical management.
Methods
A retrospective chart review was performed on six patients who underwent HCT to Cor a 1, 8, 9, and 14. None of the patients ate products containing hazelnut (PCH) at the time of HCT due to prior positive allergy testing with hIgE testing (one patient had positive SPT). Four of the patients reported tolerating PCH prior to allergy testing, one had no exposures, and one developed throat itching upon ingestion. The charts were reviewed for demographic data, birch specific IgE (bIgE), hIgE levels, SPT test results, hazelnut Cor a 1, 8, 9, and 14 levels, and trial of PCH.
Results
Average total IgE=411.11 (SD: 529.07; N: 6), hIgE=15.95 (SD=17.36; N=6), bIGE=9.57 (SD=45.06; N=6), Cor a 1=29.85 (SD=40.16; N=6), Cor a 8=0.1 (SD=1.52; N=6), Cor a 9=0.34 (SD=0.53; N=6), and Cor a 14=0.27 (SD=0.27; N=6). Five of six patients introduced PCH into their diet. Their average Cor a 1=35.80 (SD=41.84; N=5) and Cor a 9=0.12 (SD=0.06; N=5) versus the one patient who did not introduce PCH (Cor a 1=0.1 and Cor a 9=1.43).
Conclusions
This was a pilot study undertaken to investigate the utility of HCT. This study suggests that HCT can determine clinical reactivity in birch pollen allergic patients with positive hIgE.
All Author:
Joel P. Brooks, DO, Francis M. Lobo, MD
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。